Translational Medicine

Translational medicine or translational cancer medicine is a multidisciplinary approach to treat cancers. Translational medicine transforms scientific discoveries into clinical applications in order to improve the treatment response, survival rates and most importantly, the quality of life among the patients.

Translational medicine has played a pivotal role in the development of new-age anti-cancer medicines and targeted therapy protocols that come with improved efficacy and reduced toxicity.

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How does translational medicine work?

Cancers, primarily, occur due to genetic abnormalities, and translation research helps specialists identify and study these abnormalities. Translation research assists oncologists have a better understanding of the disease, develop the right treatment protocol and manage it efficiently. Translational medicine makes cancer care more targeted and personalised and thereby has a positive impact on the patient’s recovery and quality of life.

Translational Research/Medicine Department at HCG

Translational Medicine is driven by our patients, their diseases and a quest to ethically do more than available Evidence-Based Medicine. It is a disruptive yet systematic endeavour guided by a primary focus towards translational sciences spanning across the spectrum of molecular and cell biology to preclinical models to patient studies and back again, following the principles of critical path analysis and a six-sigma framework.

The Department of Translational Medicine and Therapeutics is equipped with an early phase clinical trial centre, preclinical study capabilities, regulatory expertise, a clinical trial network, medical & scientific writing team and oncology analytics capabilities and works closely with genomic researchers and clinical scientists.

Vision

Department of Translational Medicine and Therapeutics (TMT) at HCG shall be a Centre of Excellence that speeds up the rate at which oncology research can improve patient treatments and outcomes by using an interdisciplinary, highly collaborative approach that will include all components of the bench-to-bedside to the market pathway and vice-versa.

Mission

Department of Translational Medicine and Therapeutics (TMT) at HCG will create an integrated and sustainable research enterprise for viability and excellence in Patient-Oriented and Outcome-Based Research. It shall provide innovative, high-quality, cost-effective, non-clinical and clinical development services and place HCG on the World Map of Oncology Research.

Functioning

The department supports all the in-house basic and clinical translational research and has an international second opinion network for patient benefit worldwide. Apart from the in-house research activities the department functions as an interface with the Pharma-Biotech industry and makes HCG their preferred partner in oncology drug development programs across the product life cycles. The department has developed a close relationship with the “Indian Society for Clinical Research (ISCR)” as an Accredited Member Organisation of the society.

Below listed are our focus areas:

• Translational Oncology – Solid tumours and Haemato-oncology
• Immuno-oncology
• Precision Immunotherapy
• Cell-based Therapies
• Microbiome Interactions
• Tumour Microenvironment Interactions
• Translational Pathology and Digital Pathology
• Genomic Theragnostics (Genotype guided cancer therapy)
• Diagnostics Development and Drug Screening
• Cancer Infections
• Preventive Oncology, Community Engagement and Population Science
• Integrative Oncology
• Regenerative Medicine

The Department of Translational Medicine (TMT) provides services that promote a vibrant translational research and training environment at HCG.

Translational Medicine Services

• Early Phase Clinical Research Unit (CRU)
• Early Phase Oncology Study Design and Data Management
• Internal and International Second Opinion with a deep scientific dive into rare and recurrent cases
• Investigator-Initiated Studies / Real-world Research
• In-vitro and In-vivo non-clinical proof of concept studies / Pharmacology Studies
• Biomarker Research
• Regulatory Guidance and Support
• Scientific due diligence
• Clinical Data Analysis
• Medical and Scientific Writing
• Research Education and Workforce Development